Anti-TRPM4 antibody produced in rabbit
SIGMA/SAB2102584 - affinity isolated antibody
Synonym: Anti-FLJ20041; Anti-TRPM4B; Anti-Transient receptor potential cation channel, subfamily M, member 4
Product Type: Chemical
Immunoblotting Anti-TRPM4: Cat. No.SAB2102584: TRPM4 in 293T cell lysate with TRPM4 antibody at 1.0 μg/mL.
Western Blotting Western Blot of TRPM4 in Human HepG2 with TRPM4 antibody at 1 μg/mL
Western Blotting Western Blot of TRPM4 in Human Jurkat with TRPM4 antibody at 1 μg/mL
Western Blotting Western Blot of TRPM4 in Human MCF7 with TRPM4 antibody at 1 μg/mL
Western Blotting Western Blot of TRPM4 in Human 721_B with TRPM4 antibody at 1 μg/mL
Western Blotting Western Blot of TRPM4 in Human HeLa with TRPM4 antibody at 1 μg/mL
Western Blotting Western Blot of TRPM4 in Human 293T with TRPM4 antibody at 1 μg/mL
Western Blotting Western Blot of TRPM4 in Rat Brain with TRPM4 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 134 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q8TD43  |
| Biochem/physiol Actions: | TRPM4 is a calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. TRPM4 mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. TRPM4 is involved in myogenic constriction of cerebral arteries. It controls insulin secretion in pancreatic beta-cells. TRPM4 may also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human TRPM4 |
| Other Notes: | Synthetic peptide located within the following region: ELLTVYSSEDGSEEFETIVLKALVK |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |