Anti-MAP4K4, (N-terminal) antibody produced in rabbit
SIGMA/SAB2103939 - affinity isolated antibody
Synonym: Anti-FLH21957; Anti-FLJ10410; Anti-FLJ20373; Anti-FLJ90111; Anti-HGK
Product Type: Chemical
Immunohistochemistry Anti-MAP4K4, (N-terminal): Cat. No. SAB2103939: Immunohistochemistry of MAP4K4 in Liver tissue with MAP4K4 antibody at 4-8 μg/mL.
Immunoblotting Anti-MAP4K4, antibody produced in rabbit: Cat. No. SAB2103939: Immunoblotting analysis of MAP4K4 in fetal Small intestine with MAP4K4 anitbody at 1 μg/mL.
Western Blotting Western Blot of MAP4K4 in Human Stomach Tumor with MAP4K4 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 142 kDa |
| NCBI accession no. | NM_004834   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, horse, mouse, dog, rabbit, guinea pig, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O95819 |
| Biochem/physiol Actions: | MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human MAP4K4 |
| Other Notes: | Synthetic peptide located within the following region: PFIRDQPNERQVRIQLKDHIDRTRK |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |