Anti-SLC1A2 antibody produced in rabbit
SIGMA/SAB2104141 - affinity isolated antibody
Synonym: Anti-EAAT2; Anti-GLT-1
MDL Number: MFCD01092543
Product Type: Chemical
Immunohistochemistry Anti-SLC1A2: Cat. No. SAB2104141: Immunohistochemistry of SLC1A2 in Brain, cortex tissue with SLC1A2 antibody at 5.0 μg/mL.
Immunoblotting Anti-SLC1A2, antibody produced in rabbit: Cat. No. SAB2104141: Immunoblotting analysis of SLC1A2 in HT1080 cell lysate with SLC1A2 anitbody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 62 kDa |
| NCBI accession no. | NM_004171   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | guinea pig, horse, dog, rat, human, mouse, rabbit, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P43004 |
| Biochem/physiol Actions: | SLC1A2 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human SLC1A2 |
| Other Notes: | Synthetic peptide located within the following region: LVAVDWLLDRMRTSVNVVGDSFGAG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |