Anti-ZFR antibody produced in rabbit
SIGMA/SAB2104153 - affinity isolated antibody
Synonym: Anti-FLJ41312
Product Type: Chemical
Immunohistochemistry ZFR Antibody: Cat. No. SAB2104153: Immunohistochemistry analysis of ZFR in Human Lung with ZFR Antibody Antibody Concentration: 4.0-8.0 μg/mL. Cellular Data: Epithelial cells of renal tubule
Immunohistochemistry Immunohistochemistry of Rabbit Anti-ZFR in Human Pineal Tissue with Rabbit Anti-ZFR antibody at 4-8 μg/mL
Immunohistochemistry Immunohistochemistry of ZFR in heart with ZFR antibody at 4-8 μg/mL
Immunoblotting Anti-ZFR, antibody produced in rabbit: Cat. No. SAB2104153: Immunoblotting analysis of ZFR in HT1080 cell lysate with ZFR anitbody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 117 kDa |
| NCBI accession no. | NM_016107   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | bovine, rat, mouse, horse, human, rabbit, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q96KR1 |
| Application: | Anti-ZFR antibody produced in rabbit has been used in western blot analysis. |
| Biochem/physiol Actions: | Zinc finger RNA binding protein (ZFR) binds to RNA and DNA and promotes DNA repair and chromosome organisation. ZFR regulates alternative pre-mRNA splicing and suppress interferon 1 expression in tissues. ZFR is a key factor in regulating transcription in macrophages. ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. ZFR is a potent marker and therapeutic target in cancer. ZFR is highly expressed in pancreatic cancer and knockdown of which suppressed the tumor cell growth and proliferation. ZFR is overexpressed in non-small-cell lung carcinoma (NSCLC) and causes cell growth and metastasis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Zinc finger RNA binding protein (ZFR) is a highly conserved protein and is homologous to mouse ZFR. It is essential in the early developmental stages. ZFR has three N-terminal C2H2 zinc finger motifs and a C-terminal DZF (domain associated with zinc fingers) domain. ZFR is highly expressed in brain, whereas skeletal muscles is devoid of ZFR expression. In human chromosome, the gene ZFR is localized on 5p13.3. |
| Immunogen: | Synthetic peptide directed towards the middle region of human ZFR |
| Other Notes: | Synthetic peptide located within the following region: RQIHKVLGMDPLPQMSQRFNIHNNR |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |