Anti-TRPM8, (N-terminal) antibody produced in rabbit
SIGMA/SAB2104241 - affinity isolated antibody
Synonym: Anti-LTRPC6; Anti-MGC2849; Anti-TRPP8
Product Type: Chemical
Immunohistochemistry Anti-TRPM8, (N-terminal): Cat. No. SAB2104241: Immunohistochemistry of TRPM8 in Prostate tissue with TRPM8 antibody at 5.0 μg/mL.
Immunoblotting Anti-TRPM8, antibody produced in rabbit: Cat. No. SAB2104241: Immunoblotting analysis of TRPM8 in ACHN cell lysate with TRPM8 anitbody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 128 kDa |
| NCBI accession no. | NM_024080   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | bovine, rabbit, horse, human, dog, pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q7Z2W7 |
| Biochem/physiol Actions: | TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human TRPM8 |
| Other Notes: | Synthetic peptide located within the following region: YILDNNHTHLLLVDNGCHGHPTVEA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |