Anti-SPNS2, (N-terminal) antibody produced in rabbit
SIGMA/SAB2104271 - affinity isolated antibody
Synonym: Anti-DFNB115; Anti-SLC62A2; Anti-SLC63A2
Product Type: Chemical
Immunohistochemistry Anti-SPNS2, (N-terminal): Cat. No. SAB2104271: Immunohistochemistry of SPNS2 in Heart tissue with SPNS2 antibody at 5.0 μg/mL.
Immunoblotting Anti-SPNS2, antibody produced in rabbit: Cat. No. SAB2104271: Immunoblotting analysis of SPNS2 in fetal muscle tissue lysate with SPNS2 anitbody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 60 kDa |
| NCBI accession no. | NM_001124758   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q8IVW8 |
| Application: | Anti-SPNS2, (N-terminal) antibody produced in rabbit has been used in immunoblotting (1:1000)/(1:3,000). |
| Biochem/physiol Actions: | The sphingolipid transporter 2/Spinster 2 (SPNS2) protein serves as a mediator to release intracellular sphingosine-1-phosphate (S1P) and thereby regulates S1P. It might play a role in embryogenesis. Members of MFS family regulates the homeostasis in the body by transporting sugars, amino acids, ions, intermediary metabolites, and other small molecules across membranes. Lack of SPNS2 results in a significant reduction in S1P plasma levels. It plays an important role in prostate cancer, inflammatory and autoimmune diseases, and liver fibrosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The sphingolipid transporter 2/Spinster 2 (SPNS2) gene codes for a transporter of the sphingosine-1-phosphate (S1P) signaling lipid. SPNS2 is a multi-pass transmembrane protein, that belongs to the spinster (SPNS)/major facilitator superfamily (MFS) family. It has 12 transmembrane domains. SPNS2 mRNA is seen abundantly in the lung, stomach, and placenta. It is expressed at a moderate level in the cervix, small intestine, brain, skin, lymph node, and other tissues. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human SPNS2 |
| Other Notes: | Synthetic peptide located within the following region: PPGTPGTPGCAATAKGPGAQQPKPA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |