Anti-ACVR2B antibody produced in rabbit
SIGMA/SAB2105619 - affinity isolated antibody
Synonym: Anti-ACTRIIB; Anti-ActR-IIB; Anti-MGC116908
Product Type: Chemical
Immunoblotting Anti-ACVR2B: Cat. No. SAB2105619: ACVR2B in OVCAR-3 cell lysates with ACVR2B antibody at 1.0 μg/mL.
Western Blotting Western Blot of ACVR2B in Mouse Testis with ACVR2B antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 58 kDa |
| NCBI accession no. | NM_001106   |
| shipped in | wet ice |
| species reactivity | bovine, sheep, rat, horse, guinea pig, human, dog, mouse |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q13705 |
| Biochem/physiol Actions: | Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human ACVR2B |
| Other Notes: | Synthetic peptide located within the following region: KSKNVLLKSDLTAVLADFGLAVRFE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |