Anti-TGFB2 antibody produced in rabbit
SIGMA/SAB2105635 - affinity isolated antibody
Synonym: Anti-MGC116892; Anti-TGF-beta2
MDL Number: MFCD03456059
Product Type: Chemical
Immunoblotting Anti-TGFB2: Cat. No. SAB2105635: TGFB2 in NCI-H226 cell lysates with TGFB2 antibody at 1.0 μg/mL.
Western Blotting Western Blot of TGFB2 in Mouse Small Intestine with TGFB2 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 46 kDa |
| NCBI accession no. | NM_003238   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, pig, human, dog, rabbit, mouse, bovine, horse, sheep |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P61812 |
| Biochem/physiol Actions: | This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters′ anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human TGFB2 |
| Other Notes: | Synthetic peptide located within the following region: NLVKAEFRVFRLQNPKARVPEQRIE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |