Anti-CHMP4B antibody produced in rabbit
SIGMA/SAB2105902 - affinity isolated antibody
Synonym: Anti-C20orf178; Anti-CHMP4A; Anti-CTPP3; Anti-SNF7; Anti-SNF7-2
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of CHMP4B in Human Kidney with CHMP4B antibody at 4-8 μg/mL
Immunoblotting Anti-CHMP4B: Cat. No. SAB2105902: CHMP4B in THP-1 cell lysates with CHMP4B antibody at 1.0 μg/mL.
Western Blotting Western Blot of CHMP4B in Human HeLa with CHMP4B antibody at 1 μg/mL
Western Blotting Western Blot of CHMP4B in Human Lung Tumor with CHMP4B antibody at 1 μg/mL
Western Blotting Western Blot of CHMP4B in Mouse Skeletal Muscle with CHMP4B antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 25 kDa |
| NCBI accession no. | NM_176812   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | bovine, horse, dog, rabbit, rat, mouse, human, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q9H444 |
| Biochem/physiol Actions: | This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human CHMP4B |
| Other Notes: | Synthetic peptide located within the following region: EEISTAISKPVGFGEEFDEDELMAE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |