Anti-PTHLH antibody produced in rabbit
SIGMA/SAB2106317 - affinity isolated antibody
Product Type: Chemical
Immunohistochemistry Anti-PTHLH: Cat. No. SAB2106317: Immunohistochemistry of Pthlh in Lung tissue with Pthlh antibody at 5.0 μg/mL.
Immunoblotting Anti-PTHLH: Cat. No. SAB2106317: Western blot analysis of Pthlh in Mouse Brain with Pthlh (parathyroid hormone-like peptide) antibody against the middle region of Pthlh (50 μg) antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 16 kDa |
| NCBI accession no. | NM_008970   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, dog, bovine, guinea pig, goat, sheep, rabbit, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P22858 |
| Biochem/physiol Actions: | Pthlh is a neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. It regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is required for skeletal homeostasis. It promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. It upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human PTHLH |
| Other Notes: | Synthetic peptide located within the following region: EVSPNSKPAPNTKNHPVRFGSDDEG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |