Anti-ESRP2 antibody produced in rabbit
SIGMA/SAB2106589 - affinity isolated antibody
Product Type: Chemical
Immunoblotting Anti-ESRP2: Cat. No. SAB2106589: Western blot analysis of Esrp2 in Mouse Liver with Esrp2 (epithelial splicing regulatory protein 2) antibody against the C terminal of Esrp2 (50 μg) antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 77 kDa |
| NCBI accession no. | NM_176838   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rabbit, guinea pig, mouse, horse, bovine, rat, human |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q8K0G8 |
| Biochem/physiol Actions: | Esrp2 is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. It also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). It acts by directly binding specific sequences in mRNAs and binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal of human ESRP2 |
| Other Notes: | Synthetic peptide located within the following region: LLPAARVPAAATPLAYYPGPATQLY |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |