Anti-SUZ12 antibody produced in rabbit
SIGMA/SAB2107890 - affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Anti-SUZ12 (ab1): Cat. No. SAB2107890: Immunohistochemistry of SUZ12 in Placenta tissue with SUZ12 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HeLa (Cat. No. SAB2107890). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type HeLa
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 83kDa |
| NCBI accession no. | NM_015355   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, human, bovine, rat, mouse, dog, pig, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ChIP: suitable |
| immunoblotting: suitable | |
| immunohistochemistry: suitable | |
| UniProt accession no. | Q15022 |
| Biochem/physiol Actions: | A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7;17)(p15;q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human SUZ12 |
| Other Notes: | Synthetic peptide located within the following region: TGETNDKSTAPIAKPLATRNSESLH |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |