Anti-SCN5A antibody produced in rabbit
SIGMA/SAB2107930 - affinity isolated antibody
Synonym: Anti-CDCD2; Anti-CMD1E; Anti-CMPD2; Anti-HB1; Anti-HB2; Anti-HBBD; Anti-HH1; Anti-ICCD; Anti-IVF; Anti-LQT3; Anti-Nav1.5; Anti-PFHB1; Anti-SSS1; Anti-VF1
Product Type: Product-on-demand
Immunofluorescence Tissue: Skin (Cat. No. SAB2107930). Specification 1. Antibody dilution (concentration) 4-8 μg/mL
Immunoblotting Cell Type: SW620 (Cat. No. SAB2107930). Lanes 1. Antibody dilution (concentration) 0.25 μg/mL in cell type SW620
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 222kDa |
| NCBI accession no. | NM_000335   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | guinea pig, human, mouse, horse, rat, dog, rabbit, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| UniProt accession no. | Q8IZC9 |
| Biochem/physiol Actions: | SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram.The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human SCN5A |
| Other Notes: | Synthetic peptide located within the following region: FTKRVLGESGEMDALKIQMEEKFMA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |