Anti-KLF4 antibody produced in rabbit
SIGMA/SAB2107958 - affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Anti-KLF4: Cat. No. SAB2107958: Immunohistochemistry of KLF4 in Prostate tissue with KLF4 antibody at 5.0 μg/mL.
Immunohistochemistry Immunohistochemistry of KLF4 in Human lung epithelial cell with KLF4 antibody at 4-8 μg/mL
Immunoblotting Cell Type: fetal heart (Cat. No. SAB2107958). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type fetal heart
Western Blotting Western Blot of KLF4 in Human lung cell line with KLF4 antibody at 1 μg/mL
Western Blotting Western Blot of KLF4 in Mouse Kidney with KLF4 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 50kDa |
| NCBI accession no. | NM_004235   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, human, guinea pig, mouse, bovine, rat, horse, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | O43474 |
| Biochem/physiol Actions: | The mammalian Kruppel-like transcription factor, KLF4 is involved in preventing centrosome amplification following DNA damage caused by gamma-irradiation. It is both necessary and sufficient in preventing centrosome amplification following gamma-radiation-induced DNA damage and does so by transcriptionally suppressing cyclin E expression n. Kruppel-like factor 4 is also known to exhibit checkpoint function during the G1/S and G2/M transitions of the cell cycle. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human KLF4 |
| Other Notes: | Synthetic peptide located within the following region: AGCGKTYTKSSHLKAHLRTHTGEKP |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |