Anti-REC8 antibody produced in rabbit
SIGMA/SAB2108203 - affinity isolated antibody
Product Type: Product-on-demand
Immunoblotting Anti-REC8: Cat. No.SAB2108203: REC8 in 721_B cell lysate with REC8 antibody at 1.0 μg/mL.
Immunoblotting REC8: Cat. No. SAB2108203: Western blot analysis of REC8 in Human Fetal Heart cell lysates with REC8 antibody at 1.0 μg/mL.
Immunoblotting REC8: Cat. No. SAB2108203: Western blot analysis of REC8 in Human Fetal Lung cell lysates with REC8 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 62kDa |
| NCBI accession no. | NM_005132   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, horse, guinea pig, rat, bovine, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| UniProt accession no. | O95072 |
| Biochem/physiol Actions: | REC8 is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human REC8 |
| Other Notes: | Synthetic peptide located within the following region: QLQIGVIRVYSQQCQYLVEDIQHIL |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |