Anti-TXNIP antibody produced in rabbit
SIGMA/SAB2108250 - affinity isolated antibody
Product Type: Product-on-demand
Immunoblotting Anti-TXNIP: Cat. No.SAB2108250: TXNIP in Fetal Heart tissue lysate with TXNIP antibody at 1.0 μg/mL.
Western Blotting Western Blot of TXNIP in Human Fetal Lung with TXNIP antibody at 1 μg/mL
Western Blotting Western Blot of TXNIP in Mouse mesenchymal stem cell lysate with TXNIP antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 44kDa |
| NCBI accession no. | NM_006472   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rabbit, bovine, rat, dog, sheep, guinea pig, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| UniProt accession no. | Q9H3M7 |
| Biochem/physiol Actions: | TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human TXNIP |
| Other Notes: | Synthetic peptide located within the following region: DTPEAPPCYMDVIPEDHRLESPTTP |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |