Anti-PITX3 antibody produced in rabbit
SIGMA/SAB2108280 - affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Anti-PITX3, (N-terminal): Cat. No. SAB2108280: Immunohistochemistry of PITX3 in Testis tissue with PITX3 antibody at 4-8 μg/mL.
Immunoblotting Anti-PITX3, antibody produced in rabbit: Cat. No. SAB2108280: Immunoblotting analysis of PITX3 in MCF7 cell lysate with PITX3 anitbody at 1 μg/mL.
Immunoblotting PITX3: Cat. No. SAB2108280: Western blot analysis of PITX3 in Human 293T cell lysates with PITX3 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 32kDa |
| NCBI accession no. | NM_005029   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, bovine, horse, dog, sheep, human, rabbit, guinea pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | O75364 |
| Biochem/physiol Actions: | The paired-like homeodomain transcription factor 3 (PITX3) participates in the midbrain dopamine system development. The homeodomain of PITX3 is essential for DNA binding. Single-nucleotide polymorphism in this gene is linked with Parkinson′s disease. Members of RIEG/PITX homeobox family act as transcription factors. Mutations of PITX3 have been associated with anterior segment mesenchymal dysgenesis (ASMD) and congenital cataracts. PITX3 is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The paired-like homeodomain transcription factor 3 (PITX3) is located on human chromosome 10q24. It has a characteristic homeodomain. PITX3 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human PITX3 |
| Other Notes: | Synthetic peptide located within the following region: MEFGLLSEAEARSPALSLSDAGTPH |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |