Anti-HNF1A antibody produced in rabbit
SIGMA/SAB2108302 - affinity isolated antibody
Product Type: Product-on-demand
Immunohistochemistry Immunohistochemistry of HNF1A in Human Lung with HNF1A antibody at 4-8 μg/mL
Immunohistochemistry Immunohistochemistry of HNF1A in Human Liver with HNF1A antibody at 4-8 μg/mL
Immunohistochemistry Immunohistochemistry of HNF1A in Human kidney with HNF1A antibody at 4-8 μg/mL
Immunoblotting Anti-HNF1A, antibody produced in rabbit: Cat. No. SAB2108302: Immunoblotting analysis of HNF1A in OVCAR-3 cell lysate with HNF1A anitbody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 67kDa |
| NCBI accession no. | NM_000545   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, dog, mouse, guinea pig, horse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | P20823 |
| Biochem/physiol Actions: | HNF1A is required for the expression of several liver specific genes. HNF1A binds to the inverted palindrome 5′-GTTAATNATTAAC-3′. Hepatocyte nuclear factor 1α (HNF1α) modulates hepatocyte functions. It plays an important role in the modulation of gene expression and replication of hepatitis B virus (HBV). HNF1α is involved in lipid metabolism, gluconeogenesis and deoxygenation of xenobiotics. It stimulates the expression of the preS1 mRNA to induce the production of LHBs (viral large surface protein). Mutations in hepatocyte nuclear factor-1A (HNF1A) results in maturity-onset diabetes of the young type 3 (MODY3). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Hepatocyte nuclear factor 1α (HNF1α) is a transcription factor that belongs to the liver enriched transcription factor family. It has a N-terminal dimerization domain (amino acids 1–32), a POU-homeobox DNA binding domain (amino acids 150-280) and a C-terminal transactivation domain (amino acids 281-631). HNF1A is located on human chromosome 12q24. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human HNF1A |
| Other Notes: | Synthetic peptide located within the following region: HAGQGGLIEEPTGDELPTKKGRRNR |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |