Anti-GLI2
SIGMA/SAB2108467 - IgG fraction of antiserum
Synonym: Anti- THP1; Anti- THP2; Anti-HPE9
Product Type: Product-on-demand
Immunohistochemistry Anti-GLI2: Cat. No. SAB2108467: Immunohistochemistry of GLI2 in Human Intestine tissue with GLI2 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-GLI2: Cat. No. SAB2108467: Immunohistochemistry of GLI2 in Human Intestine tissue with GLI2 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. SAB2108467). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat
| accession no. | NM_030379 |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 133 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | P10070  |
| Biochem/physiol Actions: | GLI2 encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human GLI2 |
| Other Notes: | Synthetic peptide located within the following region: RNDVHLRTPLLKENGDSEAGTEPGG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |