Anti-ASCL1
SIGMA/SAB2108471 - IgG fraction of antiserum
Synonym: Anti- HASH1; Anti- MASH1; Anti- bHLHa46; Anti-ASH1
Product Type: Product-on-demand
Immunohistochemistry Anti-ASCL1: Cat. No. SAB2108471: Immunohistochemistry of ASCL1 in Human Kidney tissue with ASCL1 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: thymus (Cat. No. SAB2108471). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type thymus
| accession no. | NM_004316 |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 25 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | guinea pig, human, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | P50553  |
| Biochem/physiol Actions: | ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5′-CANNTG-3′). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human ASCL1 |
| Other Notes: | Synthetic peptide located within the following region: QSAQQQQQQQQQQQQAPQLRPAADG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |