Anti-MYC
SIGMA/SAB2108476 - affinity isolated antibody
Synonym: Anti- MRTL; Anti- bHLHe39; Anti-c-Myc
Product Type: Product-on-demand
Immunohistochemistry Anti-MYC (ab2): Cat. No. SAB2108476: Immunohistochemistry of MYC in Human Muscle tissue with MYC antibody at 4-8 μg/mL.
Immunoblotting Cell Type: transfected 293T (Cat. No. SAB2108476). Lanes 1. Antibody dilution (concentration) 0.0625 μg/mL in cell type transfected 293T
Western Blotting Western Blot of MYC in Mouse Kidney with MYC antibody at 1 μg/mL
| accession no. | NM_002467 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 50 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | guinea pig, mouse, rabbit, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | P01106  |
| Biochem/physiol Actions: | The cellular myelocytomatosis (c-myc) oncogene plays a vital role in cellular proliferation, differentiation, apoptosis and acts as transcriptional regulator of gene expression. c-Myc expression is essential and sufficient to assist most of the cells to enter synthetic (S) phase of the cell cycle. The encoded protein plays a crucial role in vasculogenesis and angiogenesis during cancer development and progression. c-Myc interacts with its binding partner Max and activates the transcription of growth promoting genes such as cyclin D2, ornithine decarboxylase and E2F1 and it also represses the transcription of multiple genes, especially p21 and p27, by binding to the transcription initiator element (Inr) in a complex with Max and either Sp1 or Miz1. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The cellular myelocytomatosis (c-myc) gene mapped to human chromosome 8q24, is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. c-myc is a member of MYC gene family. c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that regulates the G1-S cell cycle transition. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human MYC |
| Other Notes: | Synthetic peptide located within the following region: MDFFRVVENQQPPATMPLNVSFTNR |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |