Anti-TBX1
SIGMA/SAB2108485 - IgG fraction of antiserum
Synonym: Anti- CAFS; Anti- CTHM; Anti- DGCR; Anti- TGA; Anti-DGS
Product Type: Product-on-demand
Immunohistochemistry Anti-TBX1: Cat. No. SAB2108485: Immunohistochemistry of TBX1 in Human Kidney tissue with TBX1 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. SAB2108485). Lanes 1. Antibody dilution (concentration) 5.0 μg/mL in cell type Jurkat
| accession no. | NM_080647 |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 53 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | dog, rabbit, rat, human, guinea pig, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | O43435-3  |
| Biochem/physiol Actions: | TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human TBX1 |
| Other Notes: | Synthetic peptide located within the following region: PNPELRLEAPGASEPLHHHPYKYPA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |