Anti-KLB
SIGMA/SAB2108630 - affinity isolated antibody
Synonym: Anti- MGC142213; Anti-BKL
Product Type: Product-on-demand
Immunohistochemistry Anti-KLB: Cat. No. SAB2108630: Immunohistochemistry of KLB in Human Testis tissue with KLB antibody at 10 μg/mL.
Immunoblotting Cell Type: 721_B (Cat. No. SAB2108630). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type 721_B
Immunoblotting KLB Antibody: Cat. No. SAB2108630: Western Blot analysis of KLB in Human Testis cell lysates with KLB Antibody at 1.0 μg/mL.
| accession no. | NM_175737 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 120 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | rat, mouse, human, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | Q86Z14  |
| Biochem/physiol Actions: | KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human KLB |
| Other Notes: | Synthetic peptide located within the following region: DAYTIRRGLFYVDFNSKQKERKPKS |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |