Anti-OGT
SIGMA/SAB2108697 - affinity isolated antibody
Synonym: Anti- HRNT1; Anti- MGC22921; Anti- O-GLCNAC; Anti-FLJ23071
Product Type: Product-on-demand
Immunohistochemistry OGT Antibody: Cat. No. SAB2101676: Immunohistochemistry analysis of OGT in Human Pineal Tissue with OGT Antibody 5.0 μg/mL. Observed Staining: Cytoplasmic in processes of pinealocytes and endothelial cells in blood vessels
Immunoblotting Anti-OGT: Cat. No. SAB2108697: OGT in Fetal Heart tissue lysate with OGT antibody at 1.0 μg/mL.
| accession no. | NM_181672 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 117 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | dog, guinea pig, rabbit, mouse, bovine, horse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | O15294  |
| Biochem/physiol Actions: | OGT catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human OGT |
| Other Notes: | Synthetic peptide located within the following region: ASSVGNVADSTEPTKRMLSFQGLAE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |