Anti-RCAN1
SIGMA/SAB2108705 - affinity isolated antibody
Synonym: Anti- CSP1; Anti- DSC1; Anti- DSCR1; Anti- MCIP1; Anti-ADAPT78
Product Type: Product-on-demand
Immunoblotting Anti-RCAN1: Cat. No. SAB2108705: RCAN1 in Fetal Muscle tissue lysate with RCAN1 antibody at 1.0 μg/mL.
Western Blotting Western Blot of RCAN1 in Mouse Brain with RCAN1 antibody at 1 μg/mL
Western Blotting Western Blot of RCAN1 in mouse osteoclasts with RCAN1 antibody at 1 μg/mL
Western Blotting Western Blot of RCAN1 in Mouse with RCAN1 antibody at 1 μg/mL
Western Blotting Western Blot of RCAN1 in Human Fetal Muscle with RCAN1 antibody at 1 μg/mL
Western Blotting Western Blot of RCAN1 in Human HepG2 Whole Cell with RCAN1 antibody at 1 μg/mL
| accession no. | NM_004414 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 28 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | guinea pig, sheep, mouse, bovine, dog, rat, human, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| UniProt accession no. | P53805  |
| Biochem/physiol Actions: | RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human RCAN1 |
| Other Notes: | Synthetic peptide located within the following region: PVINYDLLYAISKLGPGEKYELHAA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |