Anti-MLKL
SIGMA/SAB2108746 - affinity isolated antibody
Synonym: Anti-FLJ34389
Product Type: Product-on-demand
Immunoblotting Anti-MLKL, antibody produced in rabbit: Cat. No. SAB2108746: Immunoblotting analysis of MLKL in fetal kidney tissue lysate with MLKL anitbody at 1 μg/mL.
Immunoblotting MLKL Antibody: Cat. No. SAB2108746: Western Blot analysis of MLKL in Human 293T Whole cell lysates with MLKL Antibody at 1.0 μg/mL.
Western Blotting Western Blot of MLKL in Human 786-0 Whole Cell with MLKL antibody at 1 μg/mL
Western Blotting Western Blot of MLKL in Human Lung Tumor with MLKL antibody at 1 μg/mL
| accession no. | NM_152649 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 54 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| UniProt accession no. | Q8NB16  |
| Biochem/physiol Actions: | Mixed lineage kinase domain-like protein (MLKL) primarily causes receptor-interacting protein (RIP) kinase–dependent necroptosis. However, during hepatitis, it results in programmed hepatocellular necrosis which is independent of RIPK3.s MLKL also participates in endosomal trafficking and in the formation of extracellular vesicles. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Mixed lineage kinase domain-like protein (MLKL) is encoded by the gene mapped to human chromosome 16q23. Activated MLKL is localized on the cell membrane. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human MLKL |
| Other Notes: | Synthetic peptide located within the following region: DVWKELSLLLQVEQRMPVSPISQGA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |