Anti-DPP4/CD26 antibody produced in goat
SIGMA/SAB2500328 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-ADABP; Anti-ADCP2; Anti-Adenosine deaminase complexing protein 2; Anti-CD26; Anti-
MDL Number: MFCD01094453
Product Type: Chemical
Immunohistochemistry (8μg/ml) staining of paraffin embedded Human Prostate. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
Immunohistochemistry Negative Control showing staining of paraffin embedded Human Prostate, with no primary antibody.
Flow Cytometry Flow cytometric analysis of paraformaldehyde fixed HepG2 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor™ 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor™ 488 secondary antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human, mouse, rat, canine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P27487  |
| Biochem/physiol Actions: | Dipeptidyl peptidase 4 (DPP4) or CD26 plays a vital role in T cell co-stimulation, cell-to-cell adhesion and in human immunodeficiency virus (HIV) infection. It functions as a serine protease enzyme that catalyzes the cleavage of dipeptides from peptides containing proline or alanine residues. This protein is a biomarker and therapeutic target for asthma. Deletion of the DPP4 gene affects carbohydrate metabolism which in turn leads to mental retardation and hypotonia. Abnormal expression of the protein is observed during liver regeneration, cirrhosis and liver tumorigenesis. Also, DPP4 level is reduced in serum of chronic obstructive pulmonary disease (COPD) patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Dipeptidyl peptidase 4 (DPP4), also known as cluster of differentiation 26 (CD26), is localized on T- cell surface and interacts with adenosine deaminase (ADA), collagen and CD459. The gene encoding this protein is localized on human chromosome 2q24.2. |
| Immunogen: | Peptide with sequence C-PPHFDKSKKYP from the internal region of the protein sequence according to NP_001926.2. |
| Physical form: | Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |