Anti-Proopiomelanocortin/POMC antibody produced in goat
SIGMA/SAB2500826 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-ACTH; Anti-CLIP; Anti-POC
MDL Number: MFCD00162087
Product Type: Chemical
Immunohistochemistry (2 μg/mL) staining of paraffin embedded Human Pituitary Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Immunoblotting Anti-Proopiomelanocortin / POMC: Cat. No. SAB2500826: (0.01 μg/mL) staining of NIH 3T3 lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P01189  |
| Biochem/physiol Actions: | Proopiomelanocortin (POMC) expression is regulated by hypermethylation of the upstream CpG-rich island in the gene. Mutations in the POMC gene are implicated in adrenocorticotropic hormone (ACTH) deficiency. Adrenal insufficiency and obesity are correlated to loss of function mutations in POMC. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Proopiomelanocortin (POMC) is a pro-peptide and multifunctional precursor protein for melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone ACTH. The POMC gene is mapped to human chromosome 2p23.3. It is expressed in skin, pituitary gland, and tissues of the immune system. |
| Immunogen: | Peptide with sequence C-NAIIKNAYKKGE from the C Terminus of the protein sequence according to NP_000930.1; NP_001030333.1. |
| Physical form: | Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |