Anti-EPS8 (C-terminal) antibody produced in goat
SIGMA/SAB2501392 - affinity isolated antibody, buffered aqueous solution
Synonym: Epidermal growth factor receptor pathway substrate 8
Product Type: Product-on-demand
Immunohistochemistry Anti-EPS8 (C-terminal) Cat. No. SAB2501392: (5 μg/mL) staining of paraffin embedded Human Breast Carcinoma. Steamed Antigen retrieval with citrate buffer ((pH 6)), AP-staining.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | mouse, canine, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| indirect ELISA: suitable | |
| UniProt accession no. | Q12929  |
| Biochem/physiol Actions: | EPS8 (epidermal growth factor receptor pathway substrate 8) is a substrate for tyrosine kinases, such as epidermal growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and ERBB2 (erb-b2 receptor tyrosine kinase 2). In addition, it also interacts with the Src non-receptor tyrosine kinase. The protein is involved in Rac signaling and receptor endocytosis. It also regulates dendritic cell migration, morphogenesis of intestinal cells and microvilli, and stereocilia activity. It is upregulated in pancreatic cancer and oral squamous cell carcinoma. Mutation in EPS8 is associated with autosomal recessive profound deafness. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The gene EPS8 (epidermal growth factor receptor pathway substrate 8) is mapped to human chromosome 12p12. The protein has a phosphotyrosine-binding (PTB) domain at the N-terminal, an SH3 (src homology 3) domain and an effector domain at the C-terminal. |
| Immunogen: | Peptide with sequence SGVESFDEGSSH, from the C-terminal region of the protein sequence according to NP_004438.3 |
| Physical form: | Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |