Anti-TPO antibody produced in goat
SIGMA/SAB2501722 - affinity isolated antibody, buffered aqueous solution
Synonym: MSA; TDH2A; TPX; thyroid peroxidase
Product Type: Product-on-demand
Immunoblotting Anti-TPO: Cat. No. SAB2501722: (0.3 μg/mL) staining of Human Thyroid Gland lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | goat |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P07202  |
| Biochem/physiol Actions: | Thyroid peroxidase (TPO) is involved in the biosynthesis of thyroid hormones T3 and T4. It catalyzes the oxidation of the inorganic iodide and coupling of iodinated tyrosine to produce thyroxine and triiodothyronine. Mutation in the gene increases the risk of susceptibility to autoimmune thyroiditis in patients with allergic rhinitis and asthma. Genetic deficiency of TPO is associated with the development of congenital hypothyroidism. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Thyroid peroxidase (TPO) is a membrane-bound, glycosylated, heme-containing peroxidase. It is encoded by the gene mapped to human chromosome 2p25.3. The encoded protein is a member of the human peroxidases family. TPO is a ~100 kDa protein with 933-amino acids. Mature TPO is characterized with a short transmembrane and cytoplasmic regions, as well as a dominant ectodomain, containing MPO-like, complement control protein (CCP)-like and epidermal growth factor (EGF)-like domains. |
| Immunogen: | Peptide with sequence C-TRHVIQVSNEVVTDD, from the internal region of the protein sequence according toNP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1 |
| Physical form: | Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |