Anti-th antibody produced in rabbit
SIGMA/SAB2701683 - affinity isolated antibody, buffered aqueous solution
Synonym: th; tyrosine hydroxylase
Product Type: Product-on-demand
Western Blotting Zebrafish tissue extract (30 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Th antibody (SAB2701683) diluted at 1:1000.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_571224   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | zebrafish |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:3000 |
| Application: | Anti-th antibody produced in rabbit has been used in: • western blotting (1:1000) • whole retinal flat-mount immunolabelling (1:500) • immunofluorescence (2:1000) • immunohistochemistry (2:1000) |
| Biochem/physiol Actions: | Cell surface-associated protein is implicated in virulence. Promotes bacterial attachment exclusively to the γ-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus. |
| Biochem/physiol Actions: | Tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, is essential for catecholamine biosynthesis. Its major role is to catalyze the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA). TH mainly serves as marker furcate cholaminergic neurons. Missense mutations in the TH gene are associated with Segawa′s syndrome, L-DOPA responsive infantile Parkinsonism, or L-DOPA responsive dystonia (DRD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Tyrosine hydroxylase (TH) is a cytoplasmic enzyme. The TH gene codes for a monooxygenase. |
| Immunogen: | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 111 and 450 of th according to NP_571224 |
| Physical form: | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |