Anti-FAP (AB1) antibody produced in rabbit
SIGMA/SAB2900181 - affinity isolated antibody, buffered aqueous solution
Synonym: 170-kDa melanoma membrane-bound gelatinase; FAP; FAP alpha; FAPA; Seprase; fibroblast activation protein; fibroblast activation protein alpha
Product Type: Chemical
Immunohistochemistry Anti-FAP (AB1): Cat. No.SAB2900181: Uterus: Formalin-Fixed Paraffin-Embedded (FFPE).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 10-20 μg/mL |
| UniProt accession no. | Q12884  |
| Application: | Anti-FAP (AB1) antibody produced in rabbit has been used in immunohistochemistry. |
| Biochem/physiol Actions: | Fibroblast activation protein (FAP) is expressed in several pathogenic sites including cancer, fibrosis, arthritis, wounding, or inflammation. FAP has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | FAP gene is localized on human chromosome 2q24.2. |
| General description: | Fibroblast activation protein (FAP) is a type II transmembrane serine protease and a cell surface antigen. It is present as a homodimeric integral protein with dipeptidyl peptidase IV like fold. FAP has an α/β-hydrolase domain and an eight-bladed β-propeller domain. It is not expressed in normal tissues. The protein is only expressed by activated fibroblasts in response to pathologic situations. |
| Immunogen: | Synthetic 18 amino acid peptide from extracellular domain of human FAP. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Bovine (89%); Marmoset (83%). |
| Physical form: | Solution in phosphate-buffered saline containing less than 0.1% sodium azide. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |