Anti-SHOC2 antibody produced in rabbit
SIGMA/SAB3500051 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Leucine-rich repeat protein SHOC-2; Anti-Ras-binding protein Sur-8; Anti-SOC2
Product Type: Chemical
Immunohistochemistry Anti-SHOC2: Cat. No. SAB3500051: SHOC2 in human spleen tissue with SHOC2 antibody at 5 μg/mL.
Immunoblotting Anti-SHOC2: Cat. No. SAB3500051: SHOC2 in Jurkat cell lysate with SHOC2 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_031399   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q9UQ13 |
| Biochem/physiol Actions: | Leucine-rich repeat protein SHOC2 participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Leucine-rich repeat protein SHOC-2 is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and is cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade. |
| Immunogen: | SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500051 . |
| Physical form: | Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |