Anti-SCARA5
SIGMA/SAB3500071 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Scavenger receptor class A member 5; Anti-TESR
Product Type: Chemical
Immunocytochemistry Anti-SCARA5: tCat. No. SAB3500071: SCARA5 in HepG2 cells with SCARA5 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of SCARA5 in HepG2 cells with SCARA5 antibody at 20 μg/mL.
Immunoblotting Anti-SCARA5: tCat. No. SAB3500071: SCARA5 in human liver tissue lysate with SCARA5 antibody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 24-39 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: suitable |
| immunofluorescence: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q6ZMJ2  |
| Biochem/physiol Actions: | SCARA5 (scavenger receptor class A member 5) is a tumor suppressor. It plays an important role in growth regulation. It interacts with serum ferritin and helps it in crossing the blood-retinal barrier. Changes in the expression of SCARA5 are linked with retinopathy. It might also be involved in the suppression of inflammatory fibrotic responses. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains that collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery. At least four isoforms of SCARB1 are known to exist. |
| General description: | The gene SCARA5 (scavenger receptor class A member 5) is mapped to human chromosome 8p21. It belongs to the SCARA family of proteins. |
| Immunogen: | SCARA5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SCARA5. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500071 . |
| Physical form: | Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |