Anti-CCDC134 antibody produced in rabbit
SIGMA/SAB3500074 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Coiled-coil domain containing 134
Product Type: Chemical
Immunohistochemistry Anti-CCDC134: Cat. No. SAB3500074: CCDC134 in human brain tissue with CCDC134 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of CDCC134 in human brain tissue with CDCC134 antibody at 20 μg/mL.
Immunoblotting Anti-CCDC134: Cat. No. SAB3500074: CCDC134 in rat brain tissue lysate with CCDC134 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_079097   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q9H6E4 |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines. |
| Immunogen: | CCDC134 antibody was raised against a 17 amino acid peptide near the amino terminus of human CCDC134. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500074 . |
| Physical form: | Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |