Anti-PALB2 antibody produced in rabbit
SIGMA/SAB3500079 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-FANCN; Anti-Partner and localizer of BRCA2
Product Type: Chemical
Immunoblotting Anti-PALB2: Cat. No. SAB3500079: PALB2 in SK-N-SH cell lysate with PALB2 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | Q86YC2   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: suitable | |
| UniProt accession no. | Q86YC2 |
| Application: | Anti-PALB2 antibody produced in rabbit has been used in western blot analysis. |
| Biochem/physiol Actions: | Partner and Localizer of BRCA2 (PALB2) plays a vital role in BRCA2 (breast cancer 2, early onset)-related pathways. The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51 network may allow predictions to be made of the responsiveness of a tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Partner and Localizer of BRCA2 (PALB2) gene with 13 exons is mapped to human chromosome 16p12.2. The gene codes for a 1,186 amino acid protein characterized with a coiled-coil motif at the N terminus and a C-terminal domain containing a series of WD repeats. |
| General description: | The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51ne |
| Immunogen: | PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500079 . |
| Physical form: | Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |