Anti-IRAK-M antibody produced in rabbit
SIGMA/SAB3500193 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-ASRT5; Anti-IRAKM
MDL Number: MFCD03096977
Product Type: Chemical
Immunohistochemistry Anti-IRAK-M: Cat. No. SAB3500193: Immunohistochemistry staining of rat liver cells using IRAK-M antibody at 2 μg/mL.
Immunofluorescence Immunofluorescence of IRAK-M in Rat Liver tissue with IRAK-M antibody at 10 μg/mL.
Immunoblotting Anti-IRAK-M: Cat. No. SAB3500193: Western blot analysis of IRAK-M in mouse spleen (M) and rat liver (R) tissue lysates with IRAK-M antibody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 66 kDa |
| NCBI accession no. | AF113136   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q9Y616 |
| Application: | Anti-IRAK-M antibody produced in rabbit has been used in Western blotting, immunoprecipitation and immunofluorescence. |
| Biochem/physiol Actions: | The Irakm (interleukin-1 receptor-associated kinase-3) protein downregulates the toll like receptor (TLR)-signalling and influences the action of nuclear factor-κB (NF-κB). Increased IRAKM expression is observed in inflammatory bowel disease (IBD) and colorectal cancer. It is known to reduce the immune response against microorganism. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The IRAKM (interleukin-1 receptor-associated kinase-3) gene is mapped to human chromosome 12q14.3. This gene is predominantly expressed in monocytes and macrophages. |
| Immunogen: | IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M . |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500193 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |