Anti-Clusterin antibody produced in rabbit
SIGMA/SAB3500199 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-ApoJ; Anti-Apolipoprotein J; Anti-CLI; Anti-Complement lysis inhibitor
MDL Number: MFCD01092275
Product Type: Chemical
Immunohistochemistry Anti-Clusterin: Cat. No. SAB3500199: Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 μg/mL.
Immunohistochemistry Immunohistochemistry of Clusterin in mouse brain tissue with Clusterin antibody at 5 μg/mL.
Immunofluorescence Immunofluorescence of Clusterin in human brain tissue with Clusterin antibody at 20 μg/mL.
Immunofluorescence Immunofluorescence of Clusterin in mouse brain tissue with Clusterin antibody at 20 μg/mL.
Immunoblotting Anti-Clusterin: Cat. No. SAB3500199: Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_001822   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P10909 |
| Application: | Anti-Clusterin antibody produced in rabbit has been used in immunohistochemical (IHC) staining (1:1,000 & 1:100). |
| Biochem/physiol Actions: | Clusterin (CLU) is a multifunctional plasma protein and a fluid-phase complement inhibitor. It mediates the complement terminal pathway. Clusterin is an ATP-independent small heat shock protein-like chaperone. It functions as a redox sensor and a lipid transporter. Clusterin is associated with many age-related diseases such as neurodegeneration and metabolic syndrome. It is involved in cancer progression, promotion, metastasis, and chemoresistance. Increased serum CLU levels are observed in type 2 diabetes (T2D). It is known to suppress proteotoxicity. Clusterin might show anti or proapoptotic activities. This protein is associated with different functions of the brain. A single nucleotide polymorphism (SNP) in the CLU gene might cause the development of late-onset Alzheimer′s disease (LOAD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The Clusterin (CLU) gene is mapped to human chromosome 8p21.1. The encoded protein is a chaperone and is conserved along with evolution. It is present in human tissues and fluids. |
| Immunogen: | Clusterin antibody was raised recombinant human Clusterin isoform 1. |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |