Anti-TIM-1 antibody produced in rabbit
SIGMA/SAB3500252 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-T cell immunoglobulin and mucin domain containing protein 1
Product Type: Chemical
Immunohistochemistry Anti-TIM-1: Cat. No. SAB3500252: Immunohistochemistry of TIM-1 in human uterus tissue with TIM-1 antibody at 10 μg/mL.
Immunofluorescence Immunofluorescence of TIM-1 in Human Uterus cells with TIM-1 antibody at 20 μg/mL.
Immunoblotting Anti-TIM-1: Cat. No. SAB3500252: Western blot analysis of TIM-1 in human uterus tissue lysate with TIM-1 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 40 kDa |
| NCBI accession no. | NP_036338   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q96D42 |
| Application: | Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence. |
| Biochem/physiol Actions: | Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4+ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2. |
| Immunogen: | TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500252 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |