Anti-LAMP-1 antibody produced in rabbit
SIGMA/SAB3500285 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Lysosome associated membrane protein 1
MDL Number: MFCD01864611
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of LAMP-1 in rat colon tissue with LAMP-1 antibody at 2.5 μg/mL.
Immunofluorescence Anti-LAMP-1: Cat. No. SAB3500285: Immunofluorescence of LAMP-1 in human colon tissue with LAMP-1 antibody at 20 μg/mL.
Immunoblotting
Western blot analysis of LAMP-1 in EL4 cell lysate with LAMP-1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of LAMP-1 in EL4 cell lysate with LAMP-1 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 46 kDa |
| NCBI accession no. | NP_005552   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P11279 |
| Application: | Anti-LAMP-1 antibody produced in rabbit has been used in Western blotting. |
| Biochem/physiol Actions: | Lysosomal-associated membrane protein 1 (LAMP-1) functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. LAMP-1 is essential for perforin trafficking to the lytic granules and motility of these lytic granules. Knockdown of this protein leads to inhibition of cytotoxicity of human natural killer cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Lysosomal-associated membrane protein 1 (LAMP-1) is a type I transmembrane protein with a short cytoplasmic tail containing a lysosome-targeting signal. The gene encoding this protein is localized on human chromosome 13q34. |
| Immunogen: | LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500285 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |