Anti-PKR antibody produced in rabbit
SIGMA/SAB3500326 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-
MDL Number: MFCD03455796
Product Type: Chemical
Immunohistochemistry Anti-PKR: Cat. No. SAB3500326: Immunohistochemistry of PKR in rat lung tissue with PKR antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of PKR in mouse lung tissue with PKR antibody at 20 μg/mL.
Immunoblotting Anti-PKR: Cat. No. SAB3500326: Western blot analysis of PKR in A431 whole cell lysate with PKR antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | AAP57628   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P19525 |
| Application: | Anti-PKR antibody produced in rabbit has been used in Western Blotting. |
| Biochem/physiol Actions: | EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral responses promoted by interferons. It is involved in stress response and inflammation pathways. EIF2AK2 controls the development and multiplication of cells, nutrient signaling and metabolism. The protein also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) is an intracellular protein that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. The protein contains two RNA binding domains and a kinase domain. The PKR gene is localized on human chromosome 2p22-p21. |
| Immunogen: | PKR antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PKR. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500326 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |