Anti-MDA5 antibody produced in rabbit

SIGMA/SAB3500356 - affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IFIH1; Anti-Interferon-induced with helicase C domain protein 1; Anti-Melanoma differentiation-associated protein 5

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SAB3500356-100UG	100 µg	$584.00 1/EA	Add To Favorites

Immunohistochemistry Anti-MDA5: Cat. No. SAB3500356: Immunohistochemistry of MDA5 in human lymph node tissue with MDA5 antibody at 5 μg/mL.

Immunofluorescence Immunofluorescence of MDA5 in Human Lymph Node cells with MDA5 antibody at 20 μg/mL.

Immunoblotting Anti-MDA5: Cat. No. SAB3500356: Western blot analysis of MDA5 in Daudi cell lysate with MDA5 antibody at (A) 1, (B) 2 and (C) 4 μg/mL.

Properties
Descriptions
Safety Info.
Basic Data

antibody form	affinity isolated antibody
antibody product type	primary antibodies
biological source	rabbit
clone	polyclonal
conjugate	unconjugated
form	buffered aqueous solution
mol wt	predicted mol wt 113 kDa
NCBI accession no.	NP_071451
Quality Level	100
shipped in	dry ice
species reactivity	mouse, human
storage temp.	−20°C
target post-translational modification	unmodified
technique(s)	immunofluorescence: suitable
	immunohistochemistry: suitable
	indirect ELISA: suitable
	western blot: suitable
UniProt accession no.	Q9BYX4

Application:	Anti-MDA5 antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions:	Melanoma differentiation-associated protein 5 (MDA5) plays a vital role in antiviral innate immune responses. In addition, the encoded protein also activates interferon regulatory factors 3 and 7 and nuclear factor-κB (NF-κB) via a mitochondrial viral signaling protein, inducing antiviral and proapoptotic responses, which is associated with various autoimmune diseases, such as type 1 diabetes (T1D), Graves′ disease (GD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA). Polymorphism in the gene is associated with the development of generalized vitiligo (GV).
Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits:	Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description:	Melanoma differentiation-associated protein 5 (MDA5), also known as interferon induced with helicase C domain 1 (IFIH1), is a cytosolic RNA sensor. It is encoded by the gene mapped to human chromosome 2q24.2. The encoded protein is a member of the retinoic acid-inducible gene I-like receptor family. MDA5 is characterized with both caspase recruitment domain and putative DExH group RNA helicase domains.
Immunogen:	MDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.
Other Notes:	The action of this antibody can be blocked using blocking peptide SBP3500356 .
Physical form:	Supplied in PBS with 0.02% sodium azide.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352203

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