Anti-DR4 antibody produced in rabbit
SIGMA/SAB3500428 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-TRAIL-R1
MDL Number: MFCD01864349
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of DR4 in human spleen tissue with DR4 antibody at 5 μg/mL.
Immunocytochemistry Anti-DR4: Cat. No. SAB3500428: Immunocytochemistry of DR4 in Jurkat cells with DR4 antibody at 10 μg/mL.
Immunofluorescence Immunofluorescence of DR3 in human spleen tissue with DR3 antibody at 20 μg/mL.
Immunoblotting Anti-DR4: Cat. No. SAB3500428: Western blot analysis of DR4 in HeLa total cell lysate with DR4 antibody at 1:500 dilution.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 56 kDa |
| NCBI accession no. | AAC51226   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: suitable |
| immunofluorescence: suitable | |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | O00220 |
| Application: | Anti-DR4 antibody produced in rabbit has been used in western blotting. |
| Biochem/physiol Actions: | Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulates cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkin′s lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1), also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. It belongs to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell’s apoptotic machinery. TRAIL receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L. |
| Immunogen: | DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500428 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |