Anti-LIMP2 antibody produced in rabbit
SIGMA/SAB3500449 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-CD36L2; Anti-Lysosomal integral membrane protein 2; Anti-SCARB2; Anti-SR-B2; Anti-Scavenger receptor class B member 2
Product Type: Chemical
Immunohistochemistry Anti-LIMP2: Cat. No. SAB3500449: Immunohistochemistry of LIMP2 in human skeletal muscle with LIMP2 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of LIMP2 in Human Skeletal Muscle tissue with LIMP2 antibody at 20 μg/mL.
Immunoblotting Anti-LIMP2: Cat. No. SAB3500449: Western blot analysis of LIMP2 in human skeletal muscle tissue lysate with LIMP2 antibody at 1 μg/mL in (A) the absence and (B) presence of blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 53 kDa |
| NCBI accession no. | AAH21892   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q14108 |
| Application: | Anti-LIMP2 antibody produced in rabbit has been used in immunofluorescence (1:100 |
| Biochem/physiol Actions: | Lysosomal integral membrane protein type 2 (LIMP2) binds to β-glucocerebrosidase. Mutations in the LIMP 2 gene are associated with action myoclonus-renal failure syndrome, a fatal autosomal recessive disorder. Higher levels of LIMP2 lead to enlargement of early or late endosomes/lysosomes. Overexpression of LIMP2 is associated with impairment of endocytotic membrane trafficking. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Lysosomal integral membrane protein type 2 (LIMP2) is an N-glycosylated type III transmembrane protein. It is composed of a lumenal domain, two transmembrane domains, and a cytoplasmic domain. LIMP2 belongs to the CD36 family of scavenger receptor proteins and is found abundantly in the lysosome. The LIMP2 gene is located on the human chromosome at 4q21.1. |
| Immunogen: | LIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500449 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |