Anti-TOM70 antibody produced in rabbit
SIGMA/SAB3500459 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-TOMM70A; Anti-Translocase of the mitochondrial outer membrane 70
Product Type: Chemical
Immunohistochemistry Anti-TOM70: Cat. No. SAB3500459: Immunohistochemistry of TOM70 in mouse brain tissue with TOM70 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of TOM70 in Mouse Brain tissue with TOM70 antibody at 5 μg/mL.
Immunoblotting Anti-TOM70: Cat. No. SAB3500459: Western blot analysis of TOM70 in 293 cell lysate with TOM70 antibody at 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 67 kDa |
| NCBI accession no. | NP_055635   |
| shipped in | dry ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | O94826 |
| Biochem/physiol Actions: | TOM70/ TOMM70A (translocase of outer mitochondrial membrane 70) has the capability to identify preproteins with internal hydrophobic targeting sequences. It contributes in the transportation of several large hydrophobic matrix proteins. The import receptor Tom70 acts as a docking site for cytosolic multichaperone complexes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The Tom (translocase of the mitochondrial outer membrane) complex consists of two integral membrane import receptors, Tom20 and Tom70 (translocase of outer mitochondrial membrane 70) and a GIP (general import pore) complex. TOM70/ TOMM70A has 12 coding exons and spans about 37kb. It is abundantly expressed in human tissues and is located on human chromosome 3q13.1-q13.2. It belongs to the tetratricopeptide repeat (TPR) co-chaperone family. TOM70 has a dicarboxylate TPR clamp domain that can interact with molecular chaperones like Hsp70 (heat shock protein 70)/Hsc70 and/or Hsp90. |
| Immunogen: | TOM70 antibody was raised against a 17 amino acid peptide near the amino terminus of human TOM70. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500459 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |