Anti-SIRT5 antibody produced in chicken
SIGMA/SAB3500496 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-NAD-dependent deacetylase sirtuin-5; Anti-SIR2L5; Anti-Sirtuin 5
Product Type: Chemical
Immunoblotting Anti-SIRT5: Cat. No. SAB3500496: SIRT5 in human liver tissue lysate with SIRT5 antibody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | chicken |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_036373   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: suitable | |
| UniProt accession no. | Q9NXA8 |
| Application: | Anti-SIRT5 antibody produced in chicken is suitable for western blot and indirect ELISA. |
| Biochem/physiol Actions: | SIRT5 (Sirtuin 5) is associated with metabolism and aging process. It has been reported in a study that SIRT5 influences urea cycle pathway by NAD-dependent deacetylation and subsequent activation of carbamoyl phosphate synthetase 1 (CPS1), which plays a vital role in the initial step of urea cycle for the detoxification and removal of ammonia. In non-small cell-lung cancer cells. SIRT5 contributions have also been observed for the cancer cell growth and drug resistance. Study shows that SIRT5 may possess oncogenic property. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | SIRT5 (Sirtuin 5) is a mitochondrial matrix protein belonging to the class III of the sirtuin family. It is localized inside the mitochondria and within the cytosol and nucleus. The protein is widely expressed in the brain, heart, liver and kidney. It is composed of very short amino and carboxyl terminal sequences flanking region with the conserved, catalytic sirtuin center domain. |
| Immunogen: | SIRT5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SIRT5. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500496 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |