Anti-HVCN1 antibody produced in rabbit
SIGMA/SAB3500536 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-HV1; Anti-Hydrogen voltage-gated channel 1; Anti-VSOP; Anti-Voltage sensor domain-only protein
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of HVCN1 in rat spleen tissue with HVCN1 antibody at 5 μg/mL.
Immunofluorescence Immunofluorescence of HVCN1 in Rat Spleen cells with HVCN1 antibody at 20 μg/mL.
Immunoblotting Anti-HVCN1: Cat. No. SAB3500536: HVCN1 in human spleen tissue lysate with HVCN1 antibody at (A) 0.5 and (B) 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 30 kDa |
| NCBI accession no. | NP_115745   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q96D96 |
| Biochem/physiol Actions: | Hydrogen voltage gated channel 1 (HVCN1) modulates insulin secretion by participating in Ca2+ homeostasis. In mice, the channel is involved in superoxide generation, bacterial removal from granulocytes and neutrophils and superoxide-associated B-cell receptor (BCR) signaling. HVCN1 might be associated with BCR-mediated B-cell malignancies. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Hydrogen voltage gated channel 1 (HVCN1) is a voltage gated proton channel and is needed for efflux of intracellular acid. The gene encoding it is localized on human chromosome 12q24.11. |
| Immunogen: | HVCN1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human HVCN1. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500536 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |