Anti-TCF12 antibody produced in rabbit
SIGMA/SAB3500566 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-HEB; Anti-HTF4; Anti-bHLHb20
Product Type: Chemical
Immunocytochemistry Immunocytochemistry of TCF12 in HeLa cells with TCF12 antibody at 10 μg/mL.
Immunoblotting Anti-TCF12: Cat. No. SAB3500566: TCF12 in HeLa cell lysate with TCF12 antibody at (A) 0.5 and (B) 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | AAH50556   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: suitable |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q99081 |
| Application: | Anti-TCF12 antibody produced in rabbit has been used in immunoblotting. |
| Biochem/physiol Actions: | Transcription factor 12 (TCF12) represses E-cadherin expression and thereby controls metastasis of colorectal cancer cells. TCF12 might play a role in controlling the proliferation of neural stem cells and progenitor cells. TCF12-TWIST1 (twist family bHLH transcription factor 1) heterodimers is required for the development of normal coronal suture. Mutations in the TCF12 heterodimer causes coronal craniosynostosis. TCF12 is critically required for regulating human mesodermal and hematopoietic specification in the early development. Mutations in TCF12 affects the transcriptional activity and leads to anaplastic oligodendroglioma, a rare brain tumor. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Transcription factor 12 (TCF12) is a class I member of helix-loop-helix (HLH) protein family, encodes for class II basic helix-loop-helix protein (bHLHb) transcription factor. In human chromosome, the gene TCF12 is localized on 15q21.3. |
| Immunogen: | TCF12 antibody was raised against a 19 amino acid peptide near the amino terminus of human TCF12. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500566 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |