Anti-ZIP14 antibody produced in rabbit
SIGMA/SAB3500603 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-LZT-Hs4; Anti-NET34; Anti-SLC39A14; Anti-Slc39A14; Anti-Solute carrier family 39 member A14
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of ZIP14 in mouse liver tissue with ZIP14 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of ZIP14 in Mouse Liver tissue with ZIP14 antibody at 20 μg/mL.
Immunoblotting Anti-ZIP14: Cat. No. SAB3500603: ZIP14 in human spleen tissue lysate with ZIP14 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 54 kDa |
| NCBI accession no. | NP_001128625   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: suitable |
| immunofluorescence: suitable | |
| immunohistochemistry: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q15043 |
| Application: | Anti-ZIP14 antibody produced in rabbit has been used in immunoblotting. 1:2500 |
| Biochem/physiol Actions: | Zrt- and Irt-like protein 14 (ZIP14) is a divalent metal transporter specific for zinc (Zn). However, some studies report, it also mediates the transport of manganese (Mn), iron (Fe), and cadmium (Cd). ZIP14 along with ZIP8 are prime Mn2+ importers of the brain′s capillary bed and in human brain microvascular endothelial cells (HBMVEC) in in vitro conditions. Mutations in the ZIP14 gene lead to manganese dyshomeostasis, which in turn results in manganese accumulation in childhood-onset parkinsonism–dystonia patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Solute carrier family 39 member 14 or Zrt- and Irt-like protein 14 (ZIP14), a transmembrane metal ion transporter, is a member of the LIV-1 subfamily. It contains eight transmembrane domains (TMDs), a metalloprotease, and a histidine-rich motif. ZIP14 is majorly expressed in the pancreas, liver, and heart. The ZIP14 gene is mapped to human chromosome 8p21.3. |
| Immunogen: | ZIP14 antibody was raised against a 16 amino acid peptide near the center of human ZIP14. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500603 . |
| Physical form: | Supplied in PBS with 0.02% sodium azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |