Anti-ACE2 antibody produced in rabbit
SIGMA/SAB3500977 - affinity isolated antibody
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of human kidney tissue using ACE2 antibody at 2 μg/mL.
Immunofluorescence Immunofluorescence of ACE2 in Human Kidney tissue with ACE2 antibody at 10 μg/mL.
Immunoblotting ACE2 Antibody: Cat. No. SAB3500977: Western blot analysis of ACE2 in Human kidney lysate with ACE2 antibody at 0.5 (Lane A), 1 (Lane B), and 2 (Lane C) μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 89 kDa |
| NCBI accession no. | NP_068576   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: suitable |
| immunoblotting: suitable | |
| immunofluorescence: suitable | |
| immunohistochemistry: suitable | |
| UniProt accession no. | Q9BYF1 |
| Biochem/physiol Actions: | Angiotensin-converting enzyme-2 (ACE2) as a carboxypeptidase cleaves angiotensin (Ang) I to Ang 1-9. In addition, it also degrades Ang II to Ang 1–7 and plays a vital role in regulation of blood pressure. Ace 2 aids in maintaining the balance of local renin-angiotensin system (RAS). It also helps in absorbing the neutral amino acids from the intestine and the kidney. It is a cellular receptor for spike glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is known to cause coronavirus disease 2019 (COVID-19). Downregulated expression of Ace 2 has been observed in patients with cardiovascular diseases. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Angiotensin-converting enzyme-2 (ACE2), also referred as ACEH (human ACE homolog), is an integral membrane protein. It is encoded by the gene located at human chromosome Xp22.2. Ace 2 is found in variety of tissues, but the higher levels of protein is observed in vascular endothelium, lungs, heart, kidney, and testis. The protein contains a N-terminal single catalytic metallopeptidase unit, a C-terminal noncatalytic domain and a cytoplasmic tail. |
| Immunogen: | Antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500977 . |
| Physical form: | Supplied at 1 mg/mL in PBS with 0.02% sodim azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |